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Barnidipine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Barnidipine hydrochloride图片
CAS NO:104757-53-1
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Mepirodipine (hydrochloride)
盐酸巴尼地平
YM-09730-5 hydrochloride
产品介绍
Barnidipine hydrochloride 是一种二氢吡啶类钙通道阻滞剂,对 CaA 受体具有选择性作用。它是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。

产品描述

Barnidipine hydrochloride is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery

体内活性

Barnidipine demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day[1]. Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure[2].

动物实验

Forty-one patients (mean age 69 ± 17 years, 18 females) with previously diagnosed OSA (by reduced channel home-based polysomnography) who were not being treated with continuous positive airway pressure (CPAP) because of contraindications or because of patient intolerance or rejection were evaluated. Non-dipper status was defined as the presence of a nighttime fall in systolic blood pressure (BP) which was< 10% that of daytime systolic BP as observed in a previous ambulatory blood pressure (ABP) monitoring. OSA was defined according to the presence of 5 or more episodes per hour of apnoea, hypopnoea or arousal due to respiratory effort. The reproducibility of non-dipping status was confirmed through a second 24-h ABP monitoring performed at baseline. On top of the previous stable treatment regimen (which excluded calcium-channel blockers), a 10 mg dosing of barnidipine hydrochloride at bedtime was added to all subjects during a 12-week period[2].

Cas No.

104757-53-1

分子式

C27H30ClN3O6

分子量

528.0

别名

Mepirodipine (hydrochloride);盐酸巴尼地平;YM-09730-5 hydrochloride;Barnidipine hydrochloride

储存和溶解度

DMSO:250 mg/mL (473.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years