产品描述
SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2
Cas No.
2143952-36-5
分子式
C25H38O4
分子量
402.575
别名
SH-42
储存和溶解度
Chloroform:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years