您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > CTX-0294885 hydrochloride(1439934-41-4 free base)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CTX-0294885 hydrochloride(1439934-41-4 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CTX-0294885 hydrochloride(1439934-41-4 free base)图片
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品名称
CTX-0294885 hydrochloride
CTX-0294885 hydrochloride (1439934-41-4 free base)
产品介绍

产品描述

CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent.

体外活性

CTX-0294885 is a new type of diaminopyrimidine pyrimidine, showing inhibitory activity against a variety of kinases. CTx-0294885 represents a powerful new reagent that can be used to analyze the kinase group signal network and can promote the development of targeted therapeutic strategies. Large-scale affinity purification based on CTx-0294885, followed by LC-MS / MS, can identify 235 protein kinases in MDA-MB-231 cells, including all members of the AKT family, while other AKT families have not been detected Spectral kinase inhibitor. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase enrichment can increase the number of kinase identifications to 261. Using CTx-0294885 in combination with a broad range of specific inhibitors of three other kinases, 799 high-confidence phosphate sites on 183 kinases can be identified, 10% of which are located in the activation loop and include BMP2K, MELK, HIPK2 and Phosphoric acid sites previously not reported on PRKDC.

Cas No.

T19251

分子式

C22H25Cl2N7O

分子量

474.39

别名

CTX-0294885 hydrochloride;CTX-0294885 hydrochloride (1439934-41-4 free base)

储存和溶解度

H2O:370 mg/mL (779.95 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years