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ST 2825
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ST 2825图片
CAS NO:894787-30-5
包装与价格:
包装价格(元)
5 mg电议
10 mg电议

产品介绍
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-Κb transcriptional activity.

产品描述

ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-κB transcriptional activity.

体外活性

ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization. ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at ST2825 (5 μM) and 80% inhibition at ST2825 (10 μM ) [1].

体内活性

ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. ST2825 exerts a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg. The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200 mg/kg, 5 min prior to i.p. injection with 20 μg/kg IL-1β [1].

Cas No.

894787-30-5

分子式

C27H28Cl2N4O5S

分子量

591.51

别名

ST 2825

储存和溶解度

DMSO:100 mg/mL (169.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years