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M1002
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M1002图片
CAS NO:823830-85-9
包装:500 mg
市场价:18659元

产品介绍
M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂,可以增强 HIF-2 靶基因的表达。M1002 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。

产品描述

M1002 is a hypoxia-inducible factor-2 ( HIF-2 ) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors [1].

体外活性

M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy [1]. M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors [1]. RT-PCR [1] Cell Line: 786-O cells Concentration: 10 μM Incubation Time: 24 hours Result: Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. RT-PCR [1] Cell Line: Hep3B cells Concentration: 5 μM Incubation Time: 24 hours Result: Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.

Cas No.

823830-85-9

分子式

C15H8F6N2O2S

分子量

394.29

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years