QAQ dichloride是一种可光转换的电压门控型Nav和Kv通道阻滞剂，它以反式形式 (偶氮苯光开关) 阻断通道，但不以顺式形式阻断通道。QAQ dichloride 不具备膜渗透性，只渗透表达内源性输入通道的痛觉神经元。QAQ dichloride 可以作为一种光敏缓解疼痛试剂，可用于研究急性和慢性疼痛的信号转导机制。

QAQ dichloride is a photoswitchable voltage-gated Na v and K v channels blocker. It blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain [1] [2].

QAQ dichloride (100 μM) does not cross the membrane and can be injected into cells through a micropipette to photosensitize a single cell and afford subcellular control of action potential propagation. It blocks Shaker-IR current in the trans configuration and unblocks it in the cis configuration [1]. QAQ dichloride can be used to develop red-shifted derivatives of QAQ wihch are powerful doubly charged photochromic blockers.These derivatives allow for remote control of K v and Na v channel conductance with light and offer the opportunity to silence neuronal activity reversibly [2].

1204416-85-2

C28H44Cl2N6O2

496.69

QAQ dichloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years