Darodipine 是钙离子通道的有效拮抗剂。
产品描述
Darodipine is a dihydropyridine type Ca+2 antagonist.
体内活性
Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. Darodipine (10 mg/kg; 6-month (from the 18th to the 24th month of life); p.o.) treatment restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex [2]. Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon's horn is the most sensitive to treatment with darodipine [1].
Cas No.
72803-02-2
分子式
C19H21N3O5
分子量
371.39
别名
PY-108068;PY 108-068;达罗地平;Darodipine
储存和溶解度
DMSO:60 mg/ml (161.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years