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Calcium dobesilate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calcium dobesilate图片
CAS NO:20123-80-2
包装与价格:
包装价格(元)
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Calcium dobesilate 具有血管保护特性,部分通过改善 HG 诱导的炎症来保护内皮细胞,用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等研究。

产品描述

Calcium dobesilate(CaD) has angioprotective properties and protects endothelial cells partly by ameliorating HG induced inflammation.

体外活性

CaD inhibited abnormal cell proliferation. high glucose (HG) treatment also significantly enhanced HVUEC migration compared to the control treatment. In contrast, CaD treatment partially inhibited HUVEC migration compared to HG exposure. HG?treated HUVECs exhibited increased FITC?BSA permeability compared to control cells cultured in medium alone; however, CaD application prevented the HG?induced increase in FITC?BSA permeability and suppressed HG?induced overexpression of endothelial markers (VEGF, VEGFR?2, endocan) and inflammation markers (ICAM?1, MCP?1, PTX3) in HUVECs. CaD has angioprotective properties and protects endothelial cells partly by ameliorating HG?induced inflammation[1].

细胞实验

HUVECs were seeded in 96-well culture plates (1×10^4 cells/well). Following 24 h, the control or experimental medium was added. At 12, 24, 48 and 72 h, 10 μl CCK-8 reagent was added to each well for 1 h. Absorbance values were recorded at a wavelength of 450 nm using a microplate reader[1].

Cas No.

20123-80-2

分子式

C12H10CaO10S2

分子量

418.4

别名

Calcium dobesilate

储存和溶解度

DMSO:150 mg/mL (358.50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years