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2'2'-cGAMP(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2'2'-cGAMP(sodium salt)图片
CAS NO:1465774-27-9
包装:1 mg
市场价:7969元

产品名称
2'2'-cGAMP (sodium salt)
产品介绍

产品描述

2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2'2'-cGAMP induces IFN-β production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

Cas No.

1465774-27-9

分子式

C20H24N10O13P2

分子量

674.41

别名

2'2'-cGAMP (sodium salt)

储存和溶解度

H2O:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years