Cbl-b-IN-3 (Compound 23) 是 casitas B 系淋巴瘤原癌基因-b (Cbl-b) 抑制剂，IC50为< 1 nM。 Cbl-b 是一种 E3 泛素连接酶，负调控 T 细胞活化。

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b ( Cbl-b ) inhibitor with an IC 50 of< 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation [1].

Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody [1].

2573775-59-2

C30H34F3N5O

537.62

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years