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12(S)-HpETE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
12(S)-HpETE图片
CAS NO:71774-10-2
包装:1 mg
市场价:-1元

产品介绍

产品描述

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.

Cas No.

71774-10-2

分子式

C20H32O4

分子量

336.472

别名

12(S)-HpETE

储存和溶解度

PBS (pH 7.2):0.8 mg/mL
DMSO:Miscible
DMF:Miscible
0.1 M Na2CO3:2 mg/mL
Ethanol:Miscible
Powder: -20°C for 3 years
In solvent: -80°C for 2 years