Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. It induces degradation of hypoxia inducible factor 1 α (HIF-1α) in HEK293 cells and reduces growth in a human renal cell carcinoma mouse xenograft model when administered at a dose of 0.22 mg/kg three times per week. Gramicidin A has commonly been used to study channel structure and function.

11029-61-1

C19H33N5O6

427.502

Gramicidin A

DMSO:Soluble
H2O:Slightly soluble
Ethanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years