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Zinc Pyrithione(OM-1563)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zinc Pyrithione(OM-1563)图片
CAS NO:13463-41-7
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
10g电议
50g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)317.7
FormulaC10H8N2O2S2Zn
CAS No.13463-41-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 30 mg/mL (94.4 mM)
Water:<1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)

Chemical Name: (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc

InChi Key: YZYHTCSREWDSOL-UHFFFAOYSA-O

InChi Code: InChI=1S/C5H6NOS.C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h1-5,8H;1-4H;/q2*-1;+1/p+1

SMILES Code: C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1

SynonymsOM-1563; AI3 62421; OM 1563; BC J; AI3-62421; BCJ, AI362421; BC-J OM1563; Biocut ZP, Finecide ZPT, Pyrithione zinc; Zinc pyrithione
实验参考方法
In Vitro

In vitro activity: Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential.

In VivoZinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed.
Animal model
Formulation & Dosage
References

Appl Environ Microbiol. 1995 Sep;61(9):3385-90; Environ Toxicol Chem. 2010 Nov;29(11):2583-92.