S-(+)-Ketoprofen 抑制COX-1和COX-2的IC50值分别为 1.9 和 27 nM。

Dexketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action. Dexketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as dexketoprofen trometamol, as a prescription-only drug and in Latin America as Miracox, produced by Stein in Costa Rica. In Italy it is available as an over the counter-drug under the tradename Enantyum. In Lithuania it is available as over the counter-drug uder tradename Dolmen.

22161-81-5

C16H14O3

254.285

(S)-(+)-Ketoprofen;(S)-Ketoprofen;Dexketoprofen;RP-19583;(S)-(+)-酮洛芬;右旋酮洛芬;S-(+)-Ketoprofen

DMSO:125 mg/mL (491.58 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years