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Alagebrium chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alagebrium chloride图片
CAS NO:341028-37-3
包装与价格:
包装价格(元)
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
阿拉氯胺
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
ALT711
产品介绍
Alagebrium chloride 是晚期糖基化终产物 (AGE) 抑制剂。

产品描述

Alagebrium Chloride is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic

体内活性

Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation[1].

动物实验

Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs.?This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ.?Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced.?After 4 weeks, the animals were sacrificed for histological analysis[1].

Cas No.

341028-37-3

分子式

C13H14ClNOS

分子量

267.77

别名

阿拉氯胺;4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物;ALT711;Alagebrium chloride

储存和溶解度

DMSO:25 mg/mL (93.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years