ML-SA5 是一种 MCOLN1 激动剂，通过扰乱自噬体和溶酶体之间的融合来阻止自噬通量。

ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.

Activating MCOLN1 with ML-SA5 triggers cell death of a number of cancer cells by evoking autophagic arrest and subsequent apoptotic response and cell cycle arrest, with little or no effect observed on normal cells[1].

ML-SA5 in Patu 8988 t xenograft mice profoundly suppresses tumor growth and improves survival[1].

2418670-70-7

C19H24ClN3O4S2

457.99

ML-SA5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years