NS5806 是钾电流的激活剂,可增加KV4.3/KChIP2峰值电流幅度,EC50值为 5.3 μM。它会在包含 KChIP2 的通道复合体中降低 KV4.2 和 KV4.3 电流衰减。
产品描述
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
体外活性
NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells[1][2].
Cas No.
426834-69-7
分子式
C16H8Br2F6N6O
分子量
574.07
别名
NS-5806;NS5806
储存和溶解度
DMSO:250 mg/mL (435.49 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years