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Piroxicam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:36322-90-4
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
CP-16171
吡罗昔康
产品介绍
Piroxicam 是一种非甾体抗炎剂,能够抑制COX的活性,对人单核细胞 COX-1 和 COX-2 的IC50值分别为 47 和 25 μM。

产品描述

Piroxicam is a non-specific COX inhibitor.

体外活性

Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. Piroxicam and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures. [1]

体内活性

Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. [2] Piroxicam increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. Piroxicam up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. [3] Piroxicam combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. [4] Piroxicam inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and Piroxicam does not have any direct cytotoxic effects in vitro. [5] Piroxicam also binds strongly to plasma proteins and Piroxicam could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. Piroxicam prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats. [6]

Cas No.

36322-90-4

分子式

C15H13N3O4S

分子量

331.35

别名

CP-16171;吡罗昔康;Piroxicam

储存和溶解度

Ethanol:1 mg/mL (3.01 mM)
DMSO:61 mg/mL (184.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years