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Bromfenac sodium hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bromfenac sodium hydrate图片
CAS NO:120638-55-3
包装:100 mg
市场价:1874元

产品名称
Bromfenac monosodium salt sesquihydrate
溴芬酸钠
Bromfenac Sodium
产品介绍
Bromfenac Sodium Sesquihydrate 是一种可口服的COX抑制剂,抑制COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药,有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。

产品描述

Bromfenac Sodium Sesquihydrate is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).

Cas No.

120638-55-3

分子式

C30H28Br2N2Na2O9

分子量

766.347

别名

Bromfenac monosodium salt sesquihydrate;溴芬酸钠;Bromfenac sodium;Bromfenac sodium hydrate

储存和溶解度

DMSO:35 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years