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(±)-Naringenin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Naringenin图片
CAS NO:67604-48-2
包装与价格:
包装价格(元)
25 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Naringenine
柚皮素
Naringenin
(±)-柚皮素
Salipurpol
产品介绍
(±)-Naringenin 是一种天然的类黄酮。它通过激活肌细胞中 BKCa通道发挥对内皮剥脱血管的舒张作用。

产品描述

(±)-Naringenin is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.

体内活性

(+/-)-Naringenin induced concentration-dependent relaxation in endothelium-denuded rat aortic rings pre-contracted with either 20 mM KCl or noradrenaline (pIC(50) values of 4.74 and 4.68, respectively).?Tetraethylammonium, iberiotoxin, 4-aminopyridine and 60 mM KCl antagonised (+/-)-naringenin-induced vasorelaxation, while glibenclamide did not produce any significant antagonism.?Naringin [(+/-)-naringenin 7-beta-neohesperidoside] caused a concentration-dependent relaxation of rings pre-contracted with 20 mM KCl, although its potency and efficacy were significantly lower than those of (+/-)-naringenin.?In rat tail artery myocytes, (+/-)-naringenin increased large conductance Ca(2+)-activated K(+) (BK(Ca)) currents in a concentration-dependent manner;?this stimulation was iberiotoxin-sensitive and fully reversible upon drug wash-out.?(+/-)-Naringenin accelerated the activation kinetics of BK(Ca) current, shifted, by 22 mV, the voltage dependence of the activation curve to more negative potentials, and decreased the slope of activation.?(+/-)-Naringenin-induced stimulation of BK(Ca) current was insensitive either to changes in the intracellular Ca(2+) concentration or to the presence, in the pipette solution, of the fast Ca(2+) chelator BAPTA.?However, such stimulation was diminished when the K(+) gradient across the membrane was reduced.

细胞实验

Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay[1].

Cas No.

67604-48-2

分子式

C15H12O5

分子量

272.256

别名

Naringenine;柚皮素;Naringenin;(±)-柚皮素;Salipurpol;(±)-Naringenin

储存和溶解度

H2O:< 0.1 mg/mL (insoluble)
DMSO:120 mg/mL (440.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years