NO-prednisolone is a potently stimulates IL-10 production in vivo, and isnitric oxide (NO)-releasing derivative of Prednisolone.

lipopolysaccharide induced interleukin-1 beta release from these cells was inhibited by NCX-1015 with higher potency than prednisolone.

In a chronic model of granulomatous tissue inflammation, administration of NCX-1015 (13.9 micromol kg(-1)) from day 1 (i.e. after induction of inflammation) was more effective than prednisolone in reducing the granuloma dry weight, and this was associated to a lower anti-angiogenic effect.

327610-87-7

C29H33NO9

539.57

NCX-1015;NO-泼尼松龙;NO-prednisolone

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years