JHU-083 is a selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells. JHU-083 also experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.

1998725-11-3

C14H24N4O4

312.36

JHU-083

DMSO:100 mg/mL (320.14 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years