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Paliperidone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Paliperidone图片
CAS NO:144598-75-4
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
9-hydroxyrisperidone
9-羟基利培酮
帕潘立酮
产品介绍
PaliperIDOne 是 RisperIDOne 的主要活性代谢产物,是多巴胺 D2 拮抗剂和5-HT2A拮抗剂。它用作非典型抗精神病药,用于精神分裂症的急性及维持治疗。它对α1和α2肾上腺素能受体和H1组胺能受体也有拮抗作用。

产品描述

Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.

体外活性

Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. [1] Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. [2] Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone. [3]

Cas No.

144598-75-4

分子式

C23H27FN4O3

分子量

426.492

别名

9-hydroxyrisperidone;9-羟基利培酮;帕潘立酮;Paliperidone

储存和溶解度

DMSO:4.3 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years