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Omeprazole(H 16868)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Omeprazole(H 16868)图片
CAS NO:73590-58-6
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)345.42
FormulaC17H19N3O3S
CAS No.73590-58-6 (free);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 69 mg/mL (199.8 mM)
Water:<1 mg/mL
Ethanol: 13 mg/mL (37.6 mM)
Solubility (In vivo)2% DMSO+30% PEG 300+ddH2O: 5mg/mL
SynonymsOmeprazole, H 168-68, Losec, Prilosec, Zegerid, H 16868, H 168 68
实验参考方法
In Vitro

In vitro activity: Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect.

In VivoOmeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast.
Animal model
Formulation & Dosage
ReferencesJ Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58.