CP-66948 is an antagonist of histamine H2-receptor. It has gastric antisecretory activity and mucosal protective properties.

CP-66948 inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously). The affinity of CP-66948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally. In histamine or pentagastrin-stimulated Heidenhain pouch dogs, the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os.

101189-47-3

C13H20N6S

292.4

CP-66948

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years