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JHU37160
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JHU37160图片
CAS NO:2369979-68-8
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
JHU 37160
产品介绍
JHU37160 是一种可透过血脑屏障的DREADD激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中,对hM3Dq和hM4Di DREADDs的EC50值分别为 18.5 和 0.2 nM。

产品描述

JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

体外活性

JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells

体内活性

JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice

Cas No.

2369979-68-8

分子式

C19H20ClFN4

分子量

358.85

别名

JHU 37160;JHU37160

储存和溶解度

Ethanol:72 mg/mL (200.65 mM)
DMSO:72 mg/mL (200.65 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years