Dooku1 是Yoda1 的类似物，是一种内源性Piezo1通道的选择性拮抗剂，能够抑制Yoda1 诱导的主动脉舒张。它在HEK 293 细胞以及HUVEC 中测得对2 μM Yoda1 诱导的钙离子流的IC50值分别为1.3 μM 和1.5 μM。

Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.

2253744-54-4

C13H9Cl2N3OS

326.2

Dooku1

DMSO:120 mg/mL (367.87 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years