您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Posovolone
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Posovolone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Posovolone图片
CAS NO:256955-84-7
包装与价格:
包装价格(元)
10 mg电议
100 mg电议
500 mg电议

产品名称
Co 134444
产品介绍

产品描述

Posovolone (Co 134444) is an orally active sedative-hypnotic neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.

体外活性

In mice, Co 134444 (0.5-10 mg/kg, IP, 15 min; 1-60 mg/kg, PO; 30 min) demonstrates efficacy against pentylenetetrazol (PTZ)-induced seizures with an ED 50 of 3.3 mg/kg after IP administration and 9.8 mg/kg orally. Similarly, protection against maximal electroshock (MES) is observed with an ED 50 of 4.8 mg/kg IP and 20.6 mg/kg PO. In rats, Co134444 (10-40 mg/kg; PO; 30 min) protects against PTZ-induced seizures and MES-induced seizures with an ED 50 of 23.6 mg/kg and 25.3 mg/kg, respectively[1].

Cas No.

256955-84-7

分子式

C26H40N2O3

分子量

428.61

别名

Co 134444;Posovolone

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years