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PH-002
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PH-002图片
CAS NO:1311174-68-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
PH-002 是一种抑制载脂蛋白 E4 神经内分子相互作用的抑制剂(IC50:116 nM)。

产品描述

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.

体外活性

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells (IC50: 116 nM in FRET)[1].

体内活性

PH-002 (100 nM) enhances dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons). PH-002 is also shown to enhance COX1 levels in primary neurons from the NSE-apoE4 transgenic mouse cortex and hippocampus. COX1 levels are increased by ~60% after 4 days of treatment with PH-002 (200 nM) [2].

Cas No.

1311174-68-1

分子式

C27H33N5O4

分子量

491.58

别名

PH-002

储存和溶解度

DMSO:75 mg/mL (152.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years