您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > B355252
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
B355252
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
B355252图片
CAS NO:1261576-81-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议

产品介绍
B355252 是苯氧基噻吩磺酰胺小分子,NGF受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡,保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。

产品描述

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

体外活性

Method: HT22 cells were pretreated for 2 hours with various concentrations of B355252 (0.625-20 μM). This was followed by the addition of 300 μM CoCl2 and incubation at 37oC for 24 hours. At the end of this time, cell viability was determined by resazurin assay as described below. Result: From 0.625 to 5 μM, B355252 increased cell viability in a dose-dependent manner, protecting against CoCl2-induced hypoxia. Above 5 μM, B355252 became toxic to the cells and, synergistically with CoCl2, decreased cell viability.

Cas No.

1261576-81-1

分子式

C25H24ClN3O3S2

分子量

514.06

别名

B355252

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years