PD 90780 是神经生长因子 (NGF) 的非肽拮抗剂。PD 90780 与 NGF 相互作用阻止与 p75NTR 结合。PD 90780 抑制 NGF-p75NTR 相互作用，在 PC12 和 PC12nnr5 细胞中的 IC50 值分别为 23.1 和 1.8 μM

PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.

PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR. PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR. PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM. PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively[1].

77422-99-2

C19H14N4O4

362.34

PD 90780

DMSO:28.8mg/mL (79.5mM),Need ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years