1-Methylguanidine hydrochloride 是内源性代谢产物的一种。

Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methylguanidine is synthesized from creatinine concomitant with the synthesis of hydrogen peroxide from endogenous substrates in peroxisomes. Recent evidence suggests that methylguanidine significantly inhibits iNOS activity and TNF- release. This means that methylguandine can attenuate the degree of inflammation and tissue damage associated with endotoxic shock.

21770-81-0

C2H8ClN3

109.56

1-Methylguanidine hydrochloride

DMSO:200 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years