Adarotene 是一种细胞凋亡诱导剂，通过产生 DNA 损伤，来阻止人类肿瘤细胞的增殖。

Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.

Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM [1]. Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium [2].

Adarotene (30, 40 mg/kg, p.o.) causes a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity [2]. Adarotene (15, 20 mg/kg, p.o.) leads to a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in human melanoma, MeWo, growing in nude mice [1].

496868-77-0

C25H26O3

374.47

ST1926;Adarotene

DMSO:25 mg/mL (66.76 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years