MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).

MLT-748 (2 μM, 24 hours) enhances the phosphorylation of p65 and IκBα in MALT1mut/mut patient immortalized B cells. MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S (EC50: 69 nM). MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with an affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM).

1832578-30-9

C19H19Cl2N9O3

492.32

MLT-748

DMSO:250 mg/mL (507.80 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years