BPH-1358 是一种人FPPS和UPPS抑制剂，IC50值分别为 1.8 μM 和 110 nM，对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。

BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS), with an IC50 of 110 nM.

BPH-1358 is active against S. aureus in vivo (20/20 mice survived an intraperitoneal infection model of MRSA strain)[1].

5352-53-4

C32H30Cl2N6O2

601.53

NSC50460;BPH-1358

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years