Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg.

686-07-7

C6H13NS2

163.3

Methyl Diethyldithiocarbamate

Methanol:Slightly soluble
Chloroform:Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years