Cav 3.2 inhibitor 3 (Compound 4) 是一种有效的Cav3.2 T-type Ca2+channel抑制剂，IC50为 0.1534 μM，对 D2受体的结合亲和力很小。

Cav 3.2 inhibitor 3 (Compound 4) is a potent Ca v 3.2 T-type Ca 2+ channel inhibitor with an IC 50 of 0.1534 μM, and has little binding affinity to D 2 receptors [1].

Cav 3.2 inhibitor 3 (Compound 4) (1-10 mg/kg; i.p.; once) potently suppresses T-channel-dependent somatic and visceral pain in mice [1]. Animal Model: C57BL/6J mice, Ca v 3.2-dependent somatic and visceral pain model [1] Dosage: 1, 3 and 10 mg/kg Administration: Intraperitoneal administration, once Result: Reduced the mechanical allodynia in the hindpaw and colonic pain/referred hyperalgesia following i.pl. and i.col. administrations of Na 2 S, a donor of H 2 S, respectively. Suppressed the i.pl. Na 2 S-induced paw allodynia in a dose-dependent manner, and the maximally effective doses were roughly estimated at 10 mg/kg.

C32H37N3O2

495.66

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years