NP118809 是 N 型钙通道阻滞剂，IC50值为 0.11 μM。它较弱地抑制 L 型钙通道，IC50值为 12.2 μM。

NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).

NP118809 with a total linker length of 3 carbons (n = 1) and which exhibited approximately a 500-fold increased N-type channel blockade compared to compounds in this series with linkers either shorter (n = 0, 2a) or longer (n = 2 4, (2c e). Examination of the effect of NP118809 on functional L-type calcium channel activity showed that this compound was approximately 111-fold more selective for N-type channels[1]

41332-24-5

C32H32N2O

460.621

39-1B4;1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮;NP118809

DMSO:50 mg/mL (108.55 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years