Azaserine 是一种从链霉菌属中分离出来的肿瘤抑制抗生素，可作为谷氨酰胺氨基转移酶的抑制剂。

Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.

Azaserine inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins [2]. Azaserine (25 μM) inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase, and glucosamine-6-phosphate isomerase [3].

115-02-6

C5H7N3O4

173.13

CI-337;O-Diazoacetyl-L-serine;氮杂丝氨酸;偶氮丝胺酸;P-165;Azaserine

H2O:60 mg/mL (346.56 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years