NS 11021 是特异性 Ca2+激活的大电导 K+(KCa1.1)通道激活剂。当浓度高于0.3 μM 时，它通过平行移动通道激活曲线产生更多负电位，以浓度依赖的方式激活 KCa1.1。

NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels

NS11021 increased currents sensitive to the selective BK(Ca) channel blocker, iberiotoxin (IbTX) in SMCs, but did not modulate K(+) current in HUVECs.?NS11021 reduced [Ca(2+)](i) and tension in penile arteries.?IbTX inhibited the vasorelaxation induced by NS11021 and sildenafil in human erectile tissue.?NS11021 and sildenafil but not vehicle increased erectile responses in anaesthetized rats, an effect which was abolished after pretreatment with tetraethylammonium[1].

956014-19-0

C16H9BrF6N6S

511.24

NS11021;NS 11021

DMSO:250 mg/mL (489.01 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years