Bitertanol 是一种三唑类杀菌剂。 Bitertanol 抑制去甲基化，破坏膜功能，并阻止甾醇合成。

Bitertanol is a triazole fungicide. Bitertanol inhibits demethylation, disrupts membrane function, and prevents sterol synthesis.

Bitertanol (10, 25, and 100 mg/kg) produced 2-, 4-, and 14-fold increases of 7-ethoxyresorufin O-deethylation activity in liver microsomes, respectively. Bitertanol (25 mg/kg) increased CYP1A1 protein in the liver, kidney, and lung by 10-, 13-, and 17-fold, respectively. Bitertanol produced smaller increases of CYP2B and CYP3A catalytic activity and protein than that of CYP1A1 in liver. Additions of 0.01-100 microM Bitertanol to liver microsomes from rats Bitertanol (25 mg/kg) inhibited microsomal 7-ethoxyresorufin O-demethylation activity (IC50=0.8 microM). Bitertanol (100 mg/kg) increased liver UDP-glucuronosyltransferase and glutathione S-transferase activities by 2-fold. Bitertanol (25 mg/kg) produced a minor increase in metabolic activation of benzo[a]pyrene by liver S-9 fraction in the Ames mutagenicity test while the increase was blocked by addition of 100 microM Bitertanol[2].

55179-31-2

C20H23N3O2

337.42

Biloxazol;联苯三唑醇;Sibutol;Baycor;KWG 0599;KWG0599;KWG-0599;Bitertanol

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years