Dihydrocyclosporin A 是 cyclosporin A 的密切相关的共同代谢物。它显着抑制前鞭毛体和细胞内无鞭毛体。

Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).[2].

59865-15-5

C62H113N11O12

1204.63

Dihydrocyclosporin-A;二氢环孢菌素A;Dihydrocyclosporin A

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years