N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints. D-NAME (3-10 µg/mouse) had no effect on nociception in mice assessed using the tail flick test.

50912-92-0

C7H16ClN5O4

269.69

D-NAME (hydrochloride)

PBS (pH 7.2):10 mg/mL
DMF:20 mg/mL
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years