Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM).

Neoseptin-3 causes TNFα production by macrophages in a concentration-dependent manner. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also enhance in response to Neoseptin-3. Neoseptin-3 leads to phosphorylation of IκB kinases α (IKKα), IKKβ, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IκBα, consistent with activation of MAPK and canonical NF-κB signaling. .

1622863-21-1

C29H34N2O4

474.59

Neoseptin 3

DMSO:100 mg/mL (210.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years