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CC-90001
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CC-90001图片
CAS NO:1403859-14-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
CC-90001 是口服有效的 c-Jun N 末端激酶选择性抑制剂。在基于细胞的模型中,CC-90001显示出对JNK1的选择性是JNK2的 12.9 倍。CC-90001在特发性肺纤维化方面有研究价值。

产品描述

CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.

体外活性

CC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts[1]. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM)[2].

体内活性

CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis[2]. CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis which has been confirmed by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model[2].

Cas No.

1403859-14-2

别名

CC-90001

储存和溶解度

DMSO:125 mg/mL (388.90 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years