产品描述
N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 μM, respectively). It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 μM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells. The levels of N-arachidonoyl taurine are changed in mouse brain following administration of δ9-tetrahydrocannabinol (δ9-THC).
Cas No.
119959-65-8
分子式
C22H37NO4S
分子量
411.6
别名
N-Arachidonoyl Taurine
储存和溶解度
DMF:10 mg/mL
DMSO:20 mg/mL
PBS (pH 7.2):1.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years