Raf-IN-1 是一种有效的b/cRaf抑制剂，对 cRaf、bRafwt，bRafV600E的IC50分别为 3.8 nM、36 nM、29.4 nM。Raf-IN-1 对携带 bRafV600E突变的 A375 和H358 细胞系显示细胞生长抑制作用，GI50分别为 3.4 和 2.9 nM。

RAF-IN-1 is a potent b/cRAF inhibitor with an IC 50 s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAF wt, and bRAF V600E. RAF-IN-1 shows cell growth inhibition with GI 50 s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAF V600E mutation, respectively [1].

2695505-82-7

C26H22F3N3O4

497.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years