The nuclear factor-κB (NF-Κb) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and Apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-Κb and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by Antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-Κb by CAY10512 is 0.15 μM compared to 20 μM by resveratrol.

The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 μM compared to 20 μM by resveratrol.

139141-12-1

C15H13FO

228.266

CAY10512

Ethanol:0.5 mg/mL
DMF:PBS (pH 7.2) (1:2):0.3 mg/mL
DMF:3 mg/mL
DMSO:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years