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DG172 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DG172 dihydrochloride图片
CAS NO:1361504-77-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
DG172 (dihydrochloride)
DG-172 dihydrochloride
产品介绍
DG172 dihydrochloride 是一种PPARβ/δ拮抗剂,IC50值为 27 nM。

产品描述

DG172 (dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).

体外活性

DG172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC(50) = 27 nM) and potent inverse agonistic properties.?DG172 selectively inhibited the agonist-induced activity of PPARβ/δ, enhanced transcriptional corepressor recruitment, and down-regulated transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC(50) = 9.5 nM).?Importantly, DG172 was bioavailable after oral application to mice with peak plasma levels in the concentration range of its maximal inhibitory potency, suggesting that 37 will be an invaluable tool to elucidate the functions and therapeutic potential of PPARβ/δ[1].

Cas No.

1361504-77-9

分子式

C20H22BrCl2N3

分子量

455.22

别名

DG172 (dihydrochloride);DG-172 dihydrochloride;DG172 dihydrochloride

储存和溶解度

H2O:14.29 mg/mL (31.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years