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(±)19(20)-EDP Ethanolamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)19(20)-EDP Ethanolamide图片
CAS NO:2123485-34-5
包装:1 mg
市场价:-1元

产品介绍

产品描述

(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-2 microglia stimulated by LPS and decreases LPS-induced cytotoxicity when used at concentrations ranging from 5 to 10 μM. It also decreases nitrite production when used at a concentration of 7.5 μM, an effect that can be partially reversed by the CB2 receptor antagonist AM630 and the PPARγ antagonist GW 9662 . (±)19(20)-EDP ethanolamide induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 μM) and reduces tube formation by human microvascular endothelial cells (HMVECs) in a Matrigel assay.

Cas No.

2123485-34-5

分子式

C24H37NO3

分子量

387.56

别名

(±)19(20)-EDP Ethanolamide

储存和溶解度

Ethanol:PBS(pH 7.2) (1:1):0.5 mg/mL
DMF:50 mg/mL
Ethanol:50 mg/mL
DMSO:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years